Gene expression profile of RA FLSs with or without ALKBH5 knockdown. Gene expression profile of RA FLSs with or without ALKBH5 knockdown

To investigate how ALKBH5 modulates RA FLSs functions, we conducted RNA sequencing of RA FLSs. The data were analyzed for differential expression with a nominal P<0.05. Through analysis of the input RNA-seq data, we identified significantly expressed 1956 genes(FC≥1.2). Overall design: Three biological replicates from human RA FLSs infected with scramble or ALKBH5 shRNA lentivirus