Drd2

Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including hyaloid vascular plexus regression; negative regulation of innate immune response; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including G protein-coupled dopamine receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in axon and dendrite. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Nov 2024]

该基因激活G蛋白偶联受体活性；多巴胺结合活性；以及通过Gi/Go偶联的多巴胺神经递质受体活性。涉及多种生理过程，包括玻璃体血管丛退化；先天免疫反应的负调控；以及突触前化学突触传递的调节。在多个过程中发挥作用，包括G蛋白偶联多巴胺受体信号通路；化学突触传递的调节；以及神经系统发育。位于轴突和树突中。在多个细胞成分中活跃，包括GABA能突触；多巴胺能突触；以及突触膜。在多个结构中表达，包括消化系统；泌尿生殖系统；神经系统；呼吸系统；以及感觉器官。用于研究帕金森病和原发性醛固酮增多症。该基因的人类同源基因与多种疾病相关，包括酒精依赖；药物依赖（多种）；终末期肾病；尼古丁依赖；以及2型糖尿病。与人类DRD2（多巴胺受体D2）同源。[由基因组资源联盟提供，2024年11月]