XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22

XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barnes, C.O, Bjorkman, P.J. Deposit date: 2018-02-22 Release date: 2018-05-02 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun, 9, 2018

本数据集为X射线自由电子激光（XFEL）解析的天然糖基化BG505 SOSIP.664 HIV-1包膜三聚体（Envelope Trimer）与广泛中和抗体（broadly-neutralizing antibodies）BG18及35O22复合物的晶体结构。
结构描述（Descriptor）：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[α-D-吡喃甘露糖-(1→6)-α-D-吡喃甘露糖-(1→6)]-β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等。
作者（Authors）：Barnes, C.O.、Bjorkman, P.J.
提交日期（Deposit date）：2018-02-22
发布日期（Release date）：2018-05-02
最后修改日期（Last modified）：2024-12-25
实验方法（Method）：X射线衍射（分辨率3.8 Å）
引用文献（Cite）：《结合天然糖基化HIV-1包膜的高效力V3聚糖广泛中和抗体的结构表征》，《自然通讯》（Nat Commun），第9卷，2018年