Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

ChEBI2014-12-17 更新2026-07-21 收录

黑色素瘤耐药性

EGFR表达谱分析

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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

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2014-12-17

Gene expression profiling of oncogenic NRAS driven mouse melanomas that have developed resistance to NRAS withdrawal. Mus musculus

黑色素瘤耐药性

RAS突变肿瘤

Targeted therapies have the potential to revolutionize cancer care by providing personalized treatment strategies that are less toxic and more effective but it is clear that for most solid tumors supp

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Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma

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RNA修饰机制

We performed RNA-seq to analyse the different expression genes of DTIC-resistant (DR) A375 cells and wild-type control. Examination of differentially expressed genes in DR A375 cells compared with wil

NIAID Data Ecosystem50

Honokiol Bis-Dichloroacetate (Honokiol DCA) Demonstrates Activity in Vemurafenib-Resistant Melanoma in Vivo.

黑色素瘤耐药性

基因表达分析

The majority of human melanomas bears BRAF mutations and thus is treated with inhibitors of BRAF, such as vemurafenib. While patients with BRAF mutations often demonstrate an initial dramatic response

NIAID Data Ecosystem30

Proteomics identifies markers of MAPKi resistance offering new therapeutic strategies in melanoma- Cytoplasmic (cyt), nuclear (ne) and secreted (sn) proteins of MAPKi sensitive melanoma cells

黑色素瘤耐药性

蛋白质组学生物标志物

MAPK inhibitors (MAPKi) show outstanding clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common. High-throughput, subcellular proteome analyses at two differe

NIAID Data Ecosystem60

RNA-seq melanoma. Homo sapiens

黑色素瘤耐药性

BRAF/MEK抑制剂耐药机制

Using a chromatin regulator-focused shRNA library, we found that suppression of sex determining region Y-box 10 (SOX10) in melanoma causes resistance to BRAF and MEK inhibitors. To investigate how SOX

NIAID Data Ecosystem40

Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

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