'The Metabolic Cost of Physical Rehabilitation in Mechanically Ventilated Patients in Critical Care an Observational Study dataset

<b>Background: </b>Physical rehabilitation is advocated to improve muscle strength and function after critical illness, yet interventional studies have reported inconsistent benefits. A greater insight into patients’ physiological response to exercise may provide an option to prescribe individualised, targeted rehabilitation, yet there is limited data measuring oxygen consumption (VO₂) during physical rehabilitation. We aimed to test the feasibility of measuring VO₂ during sitting and standing exercise using the Beacon Caresystem and quantify within- and between-patient variability of VO₂ percentage change.<br><b>Methods: </b>We conducted a prospective observational study on mechanically ventilated patients ventilated for ≥72 hours and able to participate in physical rehabilitation in critical care. Oxygen consumption was measured continuously using indirect calorimetry. A total of 29 measurements were taken from ten participants performing active sitting and standing exercise.<br><b>Results: </b>Median (IQR) first session baseline VO₂ was 3.54 (2.9-3.9) ml/kg/min, increasing significantly to 4.37 (3.96 – 5.14) ml/kg/min during exercise (p=0.005). The median (IQR) coefficient of variation of VO₂ percentage change in participants (n=7) that completed more than one rehabilitation session (range 2-7 sessions) was 43 (34 – 61) % in 26 measurements. The median (IQR) coefficient of variation of VO₂ percentage change was 46 (26 - 63) % in participants performing &gt;1 sitting exercise session (six participants, 19 sessions).<br><b>Conclusions: </b>VO₂ increases significantly with exercise but is highly variable between participants, and in the same participant on separate occasions performing the same functional activity. These data suggest simplified measures of function do not necessarily relate to oxygen consumption.