Ferrocenylselenoamides: Synthesis, Characterization and Cytotoxic Properties
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https://figshare.com/articles/dataset/Ferrocenylselenoamides_Synthesis_Characterization_and_Cytotoxic_Properties/2519506
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资源简介：
A new series of ferrocenyl selenoamides 7–11 (FcSeNH(CH2)nCH2(R)OH, n = 1, 2, 3, R = H,
Me, Ph) were prepared
in good yields by selenative demetalation of Fischer aminocarbene
complexes. The crystal structures of 7 [FcSeNH(CH2)2OH] and 19 [PhSeNH(CH2)2OH] reveal their capability to form intermolecular hydrogen
bonding in solid state. Results of SRB assays show that these new
selenium compounds have a good anticancer potency superior to tamoxifen
and cisplatin, with IC50 values ranging from 4.5 to 13.32
μM against human breast cancer cell lines. A preliminary model
to explain the structure–cytotoxic activity relation is proposed
where different structural parameters such as the alkyl chain length,
the presence of bulky groups in the same chain, the effect of hydroxyl
group, and also the role of ferrocene moiety are included as being
responsible for the cytotoxic response.
创建时间：
2016-02-20
