LncRNA-Seq transcriptomic profiling of the bursa of Fabricius in ALV-J-infected chickens

Avian leukemia subtype J is a tumorigenic and immunosuppressive infectious disease caused by exogenous subtype J avian leukosis virus (ALV-J), which can result in apoptosis of lymphocytes in chicken thymus, bursa, and spleen. The bursa of Fabricius is a central immune organ unique to poultry and is a site for B lymphocyte development. LncRNAs are closely related to the occurrence of diseases, such as tumors, and cell development. Presently, the expression profile of lncRNAs in bursa tissues has not been reported in chickens infected with ALV-J. In this study, Illumina HiSeq sequencing was used to obtain lncRNA expression profiles in bursa tissues in infected and healthy chickens. A series of quality assessments was conducted to verify the reliability of the datasets. The transcriptomic profiling dataset will be useful to explore and understand the molecular regulation mechanism governing the avian leukemia.