Transcriptomic analysis of dorsal and ventral subiculum after induction of acute seizures by electric stimulation of the perforant pathway in rats

Conclusion: These findings suggest preconditioning by PP electrical stimulations might induce synaptic reorganization, complement system activation, decreased glutamatergic transmission, and increased GABA transmission in subiculum areas. In the ventral subiculum, the down-regulation of proapoptotic genes and axon guidance indicates that preconditioning induces a neuroprotective environment in this region.结论：本研究结果表明，经穿通通路（perforant path, PP）电刺激预处理，可在海马下托（subiculum）区域诱导突触重构、补体系统激活、谷氨酸能神经传递减弱以及γ-氨基丁酸（GABA）能神经传递增强。在腹侧海马下托中，促凋亡基因表达下调与轴突导向相关变化提示，该预处理可在此区域构建神经保护性微环境。