DATASET FOR FACTOR V LEIDEN IN SUBJECTS WITH PREECLAMPSIA

In Ghana, there is limited information regarding factor V Leiden polymorphism on the pathogenesis of preeclampsia (PE) and its associated outcomes; hence, the focus of the current study. Eighty-one (81) consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Routine blood chemistry and characterization of Factor V Leiden were obtained for subjects. We found FVL mutation much more in PE and hypertensive patients. FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. There was an absence of FVL mutation in exon 8 in the current study. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio were observed among PE cases when stratified by FVL exons (exon 8 and 10). This study was the first to report baseline FVL genotypic and allelic frequencies as well as relating clinical variables with it.在加纳，目前针对V因子莱顿（factor V Leiden）多态性与子痫前期（preeclampsia, PE）发病机制及相关临床结局的研究资料较为匮乏，这也构成了本研究的核心主题。 本研究在获得伦理审查批准后，招募了81名签署知情同意书的受试者，并对其完成结构化问卷调查。所有受试者均接受常规血液生化检测，并进行了V因子莱顿的基因分型鉴定。 研究发现，V因子莱顿突变在子痫前期患者与高血压患者中的检出率更高。V因子莱顿第10外显子的G等位基因与A等位基因频率分别为0.67和0.33。本研究未在第8外显子中检出V因子莱顿突变。 按V因子莱顿第8、10外显子进行分层分析后可见，子痫前期患者的白细胞计数、尿酸水平均显著升高，天冬氨酸氨基转移酶/丙氨酸氨基转移酶（AST/ALT）比值升高至基线的三倍。 本研究为首个报道加纳人群V因子莱顿基线基因型与等位基因频率，并将其与临床变量进行关联分析的研究。