Additional file 1: Table S1. of Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle

Detailed features of deleted-type CNVRs on autosomes in this study. Positions are based on the UMD3.1 assembly of the bovine genome. 1 Multiple: CNVR contained more than one CNV in the same animal. Table S2. CNVR_322 with genome-wide associations with embryonic mortality. Embryonic mortality was defined by cows that received a second round of AI at 18–29 days (D), 30–60 D, 61–90 D, 91–140 D, and 141 D–parturition after the 1st AI. Table S3. Detailed features of CNVR_322 and the surrounding SNPs. Positions are based on the UMD3.1 assembly of the bovine genome. Table S4. Primer information for identification of CNVR_322 breakpoint. Positions are based on the UMD3.1 assembly of the bovine genome. Table S5. Genotype frequencies of CNVR_322 in 6364 cows and 2391 steers. Table S6. P-value of association between CNVR_322 and meat traits in 1156 Japanese Black cattle. 1 YE (%) = 69.419 + 0.13REA + 0.667RT - 0.025CW - 0.896SFT. Table S7. Number of corpora lutea and implantation sites in Anxa10 -/- and Anxa10 +/+ female mice. Table S8. Primers and probes for CNVR_322. Positions are based on the UMD3.1 assembly of the bovine genome. Table S9. Primers and probes for basic transcriptional factor 3. Positions are based on the UMD3.1 assembly of the bovine genome. Table S10. Information for multiplex PCR primers for CNVR_322. Positions are based on the UMD3.1 assembly of the bovine genome. Table S11. Primer and probe for bovine ANXA10 and mouse Anxa10 expression. Table S12. Primer information for exons 1 to 2 and exons 1 to 7 of ANXA10. (XLSX 37 kb)本研究中常染色体上缺失型拷贝数变异区域（Copy Number Variant Region, CNVR）的详细特征，其坐标均基于牛基因组UMD3.1组装版本。1 多重性：指该CNVR在同一动物个体内包含多个拷贝数变异，相关信息见表S2。CNVR_322与胚胎死亡率存在全基因组关联。胚胎死亡率的定义为：首次人工授精（Artificial Insemination, AI）后，分别在18~29天（D）、30~60天、61~90天、91~140天以及141天至分娩时接受二次人工授精的母牛。表S3：CNVR_322及其侧翼单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的详细特征，其坐标基于牛基因组UMD3.1组装版本。表S4：用于鉴定CNVR_322断裂点的引物信息，其坐标基于牛基因组UMD3.1组装版本。表S5：CNVR_322在6364头母牛与2391头阉牛中的基因型频率。表S6：1156头日本黑牛中CNVR_322与肉用性状关联的P值，计算公式为：YE(%) = 69.419 + 0.13REA + 0.667RT - 0.025CW - 0.896SFT。表S7：Anxa10基因敲除型（Anxa10 -/-）与野生型（Anxa10 +/+）雌性小鼠的黄体数与着床位点数量。表S8：用于CNVR_322检测的引物与探针信息，其坐标基于牛基因组UMD3.1组装版本。表S9：用于基础转录因子3（Basic Transcription Factor 3）的引物与探针信息，其坐标基于牛基因组UMD3.1组装版本。表S10：CNVR_322的多重聚合酶链式反应（Polymerase Chain Reaction, PCR）引物信息，其坐标基于牛基因组UMD3.1组装版本。表S11：用于牛ANXA10与小鼠Anxa10基因表达检测的引物与探针。表S12：ANXA10基因第1~2外显子与第1~7外显子的引物信息（XLSX格式，大小37 KB）。