HHV-6B infection in the presence of shRNA to U28

Human herpesviruses 6B (HHV-6B) belongs to roseolovirus genus of betaherpesvirus subfamily and causes exanthema subitum and encephalitis. Viral ribonucleotide reductase (RNR; U28) is conserved in betaherpesviruses but it has lost enzymatic activity. We analyzed the role of U28 in infected cells