Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-90fd5f68-19 (Mpro-P2218)

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-90fd5f68-19 (Mpro-P2218) Descriptor: 3C-like proteinase, 4-[2-(3-chlorophenyl)acetamido]isoquinoline-6-carboxamide, CHLORIDE ION, ... Authors: Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F. Deposit date: 2023-08-11 Release date: 2023-11-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.738 Å) Cite: Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

团体提交的、由COVID Moonshot项目提供抑制剂的新型冠状病毒（SARS-CoV-2）主蛋白酶复合物晶体结构——新型冠状病毒主蛋白酶与MAT-POS-90fd5f68-19（Mpro-P2218）结合的晶体结构
描述项：3C样蛋白酶（3C-like proteinase）、4-[2-(3-氯苯基)乙酰胺基]异喹啉-6-甲酰胺、氯离子（CHLORIDE ION）等
作者：Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F
沉积日期：2023-08-11
发布日期：2023-11-08
最后更新日期：2023-12-06
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.738埃（Å）
引用文献：《强效非共价新型冠状病毒主蛋白酶抑制剂的开放科学发现》，《科学》（Science），第382卷，2023年