Global transcriptional analysis of S. mutans metalloregulation

Multiple S. mutans genes that are subject to SloR control are likely contributors to virulence. The regulation of these genes in response to metal ion limitation vs. availability in the oral cavity can significantly facilitate the caries-forming process and hence continued analysis of these data can reveal novel candidate genes for the purposes of therapeutic intervention and/or prevention. Keywords: Genetic modification, dose response, metalloregulation Analyses were based on a comparison between low Mn and high Mn groups (paired comparisons A, B, and C) and the monitoring of gene expression in the presence (WT) or absence (mutant) of SloR under moderate Mn content. Analysis of significance amongst all genes and the formulation of hypotheses that are relevant to the cariogenic state were performed.