Effect of Prebiotic Inulin in Gut microbiome Changes in APOE mice

APOE4 carriers have reduced cerebral blood flow (CBF) and increased amyloid-beta aggregation and gut dysbiosis decades before AD onset. Female APOE4 carriers show a greater risk for AD. Intervention that can reverse the course would be critical to mitigating AD risk for APOE4 carriers. Our goal was to investigate whether the early intervention of a prebiotic inulin diet can mitigate gut dysbiosis. Four-month-old, asymptomatic APOE3 and APOE4 mice were fed with inulin or a cellulose control diet for four months. Fecal samples were collected for gut microbiome sequencing at the end of the study.