Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction

Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction Descriptor: (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid, 4-aminobutyrate aminotransferase, mitochondrial, ... Authors: Mascarenhas, R, Juncosa, J.I, Takaya, K, Le, L.V, Moschitto, M.J, Silverman, R.B, Liu, D. Deposit date: 2017-10-02 Release date: 2018-02-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. J. Am. Chem. Soc., 140, 2018

结合一款用于成瘾治疗的强效灭活剂(S)-3-氨基-4-(二氟亚甲基)环戊-1-烯-1-羧酸的γ-氨基丁酸（GABA）氨基转移酶（GABA Aminotransferase）晶体结构。描述项：(3R,4E)-4-[({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}甲基)亚氨基]环戊-1-烯-1,3-二羧酸、线粒体4-氨基丁酸氨基转移酶……。作者：Mascarenhas R、Juncosa J.I、Takaya K、Le L.V、Moschitto M.J、Silverman R.B、Liu D。入库日期：2017-10-02；发布日期：2018-02-14；最后修改日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.95埃（Å）。引用文献：《用于成瘾治疗的强效γ-氨基丁酸氨基转移酶灭活剂(S)-3-氨基-4-(二氟亚甲基)环戊-1-烯-1-羧酸的设计与作用机制》，刊载于《美国化学会志》（J. Am. Chem. Soc.），2018年，第140卷。