NCOR1 ChIP-seq analysis of WT naive CD4+ T cells

The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we identified genome-wide binding sites of the cofactor NCOR1 in naive CD4+ T cells by using ChIP-seq. Genome-wide NCOR1 binding peaks in naive CD4+ T cells were identified by combining ChIPmentation (doi:10.1038/nmeth.3542) and next generation sequencing.