Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35

Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. Deposit date: 2021-06-18 Release date: 2021-09-08 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021

与SHU9119结合的黑皮质素1受体（melanocortin-1 receptor）与Gs蛋白及Nb35形成复合物的冷冻电镜（Cryo-EM）结构
描述项：钙离子（CALCIUM ION）、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1（Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1）等
作者：Ma, S、Chen, Y、Dai, A、Yin, W、Guo, J、Yang, D、Zhou, F、Jiang, Y、Wang, M.-W、Xu, H.E.
提交日期：2021-06-18
发布日期：2021-09-08
最后更新日期：2025-07-02
研究方法：电子显微镜（ELECTRON MICROSCOPY），分辨率3.1埃
引用文献：人源黑皮质素1受体（human melanocortin-1 receptor）介导钙离子依赖的激素识别与Gβ相互作用的结构机制. 《细胞研究（Cell Research）》, 第31卷, 2021年