Loss of MeCP2 function is associated with distinct gene expression changes in the striatum

ChEBI2013-07-13 更新2026-07-21 收录

神经发育障碍分子机制

脑区特异性基因表达谱

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Loss of MeCP2 function is associated with distinct gene expression changes in the striatum

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2013-07-13

AUTS2 forms a novel complex to recruit CUL4 E3 for BMP inhibition and neural differnetiation

神经发育障碍分子机制

神经分化调控

Neurodevelopmental disorders (NDD) present a great challenge for medicine due to their complicated etiology and diverse genetic lesions. Although many risk genes have been identified, we know little a

NIAID Data Ecosystem70

Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in Neurodevelopmental Disorders. Homo sapiens

神经发育障碍分子机制

iPSC疾病模型

The cellular and molecular mechanisms underlying neurodevelopmental conditions such as autism spectrum disorders have been studied intensively for decades. The ability to generate patient-specific ind

NIAID Data Ecosystem40

Title: Neurodevelopmental and behavioral defects in congenital heart disease

先天性心脏病神经发育

神经发育障碍分子机制

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease associated with microcephaly and poor neurodevelopmental outcomes. Here we show that the Ohia HLHS mouse model, with mutatio

NIAID Data Ecosystem20

Molecular pathogenesis of several neurodevelopmental disorders converges on MeCP2-TCF20 complex interactions

神经发育障碍分子机制

MeCP2蛋白

Neurodevelopmental disorders (NDDs) are genetically heterogeneous, yet often share certain features such as intellectual disability or motor incoordination. MeCP2 dysfunction is associated with MECP2

NIAID Data Ecosystem60

Additional file 5 of ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case

神经发育障碍分子机制

差异表达基因分析

Additional file 5: List of differentially expressed genes in the ADNP patient-derived lymphoblastoid cell lines as compared to age- and sex-matched control lymphoblastoid cell lines using the DESeq2 a

Figshare2024-10-25 更新30

Loss of MeCP2 function is associated with distinct gene expression changes in the striatum

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