Deviation of simulated results from clinical data, expressed for each quantity as relative RMSE (root mean squared error) and as average error on the profile.

Since no statistically significant differences between sessions were found, the median values reported were calculated pooling HD1 and HD3. Note that for interstitial fluid (ISV) and intracellular (ICV) volumes, RMSE was calculated only on one point, and thus simply represents the average error scaled on the data. Global RMSE is the output of the objective function in Eq 13. Measurement uncertainties for solutes assays come from the manufacturer of the equipment. For uncertainty on BCM measurements, see [53]).