Control of Oxygen Atom Chirality and Chelate Ring Conformation by Protected/Free Sugar Hydroxyl Groups in Glucose-Pendant Dipicolylamine−Copper(II) Complexes

A pair of copper(II) complexes 1 and 2 exhibit an enantiomeric
chiral center at the oxygen atom that coordinates to the metal
center. The configurations of the oxygen atom chirality and the
chelate ring conformation are simply controlled by protected/free
hydroxyl groups of the sugar moiety, yielding mirror image CD
spectra. In this system, repulsive and attractive forces are used
to regulate chirality on the copper-coordinated oxygen atom both
in the solid state and in solution.

一对铜(II)配合物1和2在氧原子处展现出一个手性中心，该中心与金属中心配位。氧原子手性配置和螯合环构象的调控单纯依赖于糖基团中保护性/自由羟基，从而产生镜像CD光谱。在此体系中，通过排斥力和吸引力的相互作用，在固态和溶液中均能对铜配位氧原子上的手性进行调节。