Accelerating Whole-Sample Polarization-Resolved Second Harmonic Generation imaging in Mammary Gland Tissue via Generative Adversarial Networks

Authors:

Arash Aghigh, Jysiane Cardot, Melika Saadat Mohammadi, Gaëtan Jargot, Heide Ibrahim, Isabelle Plante, François Légaré

Affiliations:

    1.    Centre Énergie Matériaux Télécommunications, Institut National de la Recherche Scientifique, Varennes, Québec, Canada.    2.    Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Québec, Canada.

Corresponding Author:

Arash Aghigh, [e-mail]

Description:

This dataset accompanies the research on improving whole-sample Polarization-Resolved Second Harmonic Generation (P-SHG) imaging in mammary gland tissue using Enhanced Super-Resolution Generative Adversarial Networks (ESRGAN). The novel approach significantly reduces imaging time while maintaining high image quality and analytical accuracy, demonstrating a reduction in imaging time by more than 95%. This method also minimizes laser-induced photodamage, lowers costs of optical components, and increases the accessibility and applicability of P-SHG imaging in various fields.

Keywords:

Polarization-Resolved Second Harmonic Generation, P-SHG, Generative Adversarial Networks, GAN, ESRGAN, Mammary Gland Imaging, Super-Resolution, Image Upscaling, Deep Learning, Biomedical Imaging

Funding Information:

    •    Canada Foundation for Innovation    •    Fonds de recherche du Québec–Nature et technologies    •    Natural Sciences and Engineering Research Council of Canada    •    New Frontiers Research Fund    •    NSERC CREATE program (scholarship for Arash Aghigh)

Related Identifiers:

    •    GitHub repository for ChaiNNer program: https://github.com/chaiNNer-org/chaiNNer    •    Download links for models used: https://openmodeldb.info

Additional Information:

Animal studies were conducted according to the procedures provided by the Canadian Council on Animal Care. The protocol (2005-02) was reviewed and approved by the Institutional Committee for Animal Protection of the Laboratoire National de Biologie Expérimentale (LNBE), the animal facilities based at the Institut National de Recherche Scientifique (INRS).