IL10RB as shared component in several class II cytokine receptor complexes

Figure 6.The IL-10R2 chain is a shared component in several class II cytokine receptor complexes. The second chain of the IL-10R complex, IL-10R2, is a common component of several class II cytokine receptor complexes, including the receptors for IL-10, IL-22, IL-26, and IFN-Lambda (IL-28/IL-29). Although the IL-10R2 chain is broadly expressed on most cell types, expression of the ligand-binding chains IL-10R1, IL-22R1, IL-20R1, and IFN-LambdaR1 (IL-28R) is limited to only certain cell types or tissues. Signaling through these receptor complexes results in preferential activation of specific STATs. This in turn results in the activation of distinct, gene-expression profiles.