PLA2G5

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

本基因隶属于分泌型磷脂酶A2家族。其位于第1号染色体上紧密连锁的分泌型磷脂酶A2基因簇中。所编码的酶催化膜磷脂的水解，生成溶血磷脂和包括花生四烯酸在内的游离脂肪酸。该酶优先水解含亚油酰基的磷脂酰胆碱底物。据推测，该酶的分泌可诱导邻近细胞产生炎症反应。已发现存在选择性剪接的转录变体，但其全长性质尚未确定。[由RefSeq提供，2008年7月]