Data_Sheet_1_Electroconvulsive Therapy-Induced Changes in Functional Brain Network of Major Depressive Disorder Patients: A Longitudinal Resting-State Electroencephalography Study.docx

ObjectivesSeveral studies have shown abnormal network topology in patients with major depressive disorder (MDD). However, changes in functional brain networks associated with electroconvulsive therapy (ECT) remission based on electroencephalography (EEG) signals have yet to be investigated.MethodsNineteen-channel resting-state eyes-closed EEG signals were collected from 24 MDD patients pre- and post-ECT treatment. Functional brain networks were constructed by using various coupling methods and binarization techniques. Changes in functional connectivity and network metrics after ECT treatment and relationships between network metrics and clinical symptoms were explored.ResultsECT significantly increased global efficiency, edge betweenness centrality, local efficiency, and mean degree of alpha band after ECT treatment, and an increase in these network metrics had significant correlations with decreased depressive symptoms in repeated measures correlation. In addition, ECT regulated the distribution of hubs in frontal and occipital lobes.ConclusionECT modulated the brain’s global and local information-processing patterns. In addition, an ECT-induced increase in network metrics was associated with clinical remission.SignificanceThese findings might present the evidence for us to understand how ECT regulated the topology organization in functional brain networks of clinically remitted depressive patients.

研究目标：多项研究表明，重度抑郁症（MDD）患者存在异常的网络拓扑结构。然而，基于脑电图（EEG）信号，关于电休克治疗（ECT）后功能性脑网络变化的研究尚待深入。研究方法：从24名MDD患者中收集了19通道静息状态闭眼EEG信号，在ECT治疗前后进行。通过多种耦合方法和二值化技术构建了功能性脑网络。探讨了ECT治疗后的功能连接和网络指标变化，以及网络指标与临床症状之间的关系。研究结果：ECT治疗显著增加了全局效率、边缘介数中心性、局部效率和α波带的平均度，这些网络指标的增加与重复测量的抑郁症状减少呈显著相关性。此外，ECT调节了额叶和枕叶中枢纽的分布。研究结论：ECT调节了大脑的全球和局部信息处理模式。此外，ECT引起的网络指标增加与临床缓解相关。研究意义：这些发现可能为我们提供证据，以理解ECT如何调节临床缓解抑郁患者功能性脑网络的拓扑组织。