Longitudinal Mult-omics Study of Palbociclib Resistance in Hormone Receptor (HR) Positive/Human Epidermal Growth Factor Receptor (HER) 2 Negative Metastatic Breast Cancer (MBC)

A comprehensive genomic and transcriptomic analysis of pre-treatment and post-treatment tumors from Asian metastatic breast cancer patients treated with palbociclib plus endocrine therapy identified novel markers associated with poor prognosis. whole transcriptome sequencing of pre-treatment (Baseline) and post-treatment (PD) tumors from 67 breast cancer patients treated with palbociclib plus endocrine therapy by Illumina Hiseq 2500 Raw data files are submitted to EGA with the accession number EGAS00001005736