Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate

Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate Descriptor: 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, Thymidylate synthase Authors: Dowiercial, A, Jarmula, A, Rypniewski, W.R, Wilk, P, Kierdaszuk, B, Rode, W. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate PTERIDINES, 2013

小鼠胸苷酸合酶（Thymidylate synthase）与底物类似物及强效抑制剂N(4)-羟基-2'-脱氧胞苷-5'-单磷酸形成二元复合物的晶体结构。组分描述：2'-脱氧-N-羟基胞苷5'-二氢磷酸酯、甘油（GLYCEROL）、胸苷酸合酶。作者：Dowiercial A、Jarmula A、Rypniewski W.R、Wilk P、Kierdaszuk B、Rode W。沉积日期：2012-04-05；发布日期：2013-04-10；最后修改日期：2023-09-13。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.75埃（Å）。引用文献：小鼠胸苷酸合酶分别单独与N4-OH-dCMP结晶，或在N5,10-亚甲基四氢叶酸存在下结晶的复合物晶体结构，刊载于《PTERIDINES》，2013年。