Sonic hedgehog fusion-negative rhabdomyosarcoma orgiginates from endothelial progenitors. Mus musculus

Genetic fate mapping was preformed on aP2-Cre;tdTomato and aP2-Cre;tdTomato;SmoM2/+ animals and endothelial progenitor cells identified as the cell of origin of FN-RMS in aP2-Cre;SmoM2/+ animals Overall design: mononucular cells were isolated from aP2-Cre;tdTom sternocleidomastoid muscle and aP2-Cre;tdTom;SmoM2/+ tumors and discreet populations collected by FACS