Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution Descriptor: (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Frydenvang, K, Kastrup, J.S. Deposit date: 2015-07-01 Release date: 2015-12-30 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.801 Å) Cite: Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59, 2016

分辨率达1.8埃的、与拮抗剂(R)-2-氨基-3-(3'-羟基联苯-3-基)丙酸形成复合物的谷氨酸受体2（GluA2）配体结合结构域(S1S2J)的晶体结构。描述符：(R)-2-氨基-3-(3'-羟基联苯-3-基)丙酸、1,2-乙二醇、氯离子……作者：Frydenvang K、Kastrup J.S.。提交日期：2015-07-01；发布日期：2015-12-30；最后修改日期：2024-10-09。实验方法：X射线衍射（1.801 Å）。引用文献：《芳基取代苯丙氨酸的研究：AMPA受体的合成、活性及不同结合模式》，刊载于《药物化学杂志》(J.Med.Chem.)，第59卷，2016年。