首页/数据集/Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies

NIAID Data Ecosystem2026-03-13 收录

合成致死机制

ARID1A缺陷

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125221 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-09-03

母细胞瘤治疗靶点

合成致死机制

Despite the identification of MYCN amplification as an adverse prognostic marker in neuroblastoma, MYCN inhibitors have yet to be developed. Here, by integrating evidence from a whole genome shRNA lib

NIAID Data Ecosystem70

Supplementary Table 1 from Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies

胰腺癌药物敏感性

合成致死机制

IC50 and PTGR1 expression

NIAID Data Ecosystem50

Dysregulated synthetic lethal genes in human cancer

合成致死机制

肿瘤转录组缓冲

To maintain cell fitness, the deleterious effects of gene defects are often buffered by compensatory changes in additional genes. In cancer, these buffering processes could, in principle, be targeted

NIAID Data Ecosystem20

Synthetic lethality by TET-dioxygenase inhibition

癌症靶向治疗

合成致死机制

To characterize target specificity of TETi76, we performed global gene expression analyses of K562TET2+/+ and TET2-/- control cells; TETi76 mimicked expression signatures generated by the loss of TET2

NIAID Data Ecosystem50

Ubiquitinated PCNA drives USP1 synthetic lethality in cancer

合成致死机制

USP7抑制剂

CRISPR Cas9-based functional genomics screening is a powerful approach for identifying and characterizing novel oncology drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitina

NIAID Data Ecosystem30

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies

资源简介：

相关数据集