Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom.

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom. Descriptor: Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter Authors: Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. Deposit date: 2022-11-11 Release date: 2024-05-15 Last modified: 2025-07-23 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024分辨率为3.0埃的内向开放构象、结合抗抑郁药安非他酮的人类去甲肾上腺素转运体（norepinephrine transporter, NET）的冷冻电镜（Cryo-EM）结构。描述符：安非他酮、氯离子、钠依赖性去甲肾上腺素转运体。作者：Tan J、Xiao Y、Kong F、Lei J、Yuan Y、Yan C。存档日期：2022-11-11。发布日期：2024-05-15。最近修改日期：2025-07-23。方法：电子显微镜（3埃）。引用：《人类去甲肾上腺素转运体再摄取与抑制的分子基础》，《自然》（Nature），632卷，2024年。