Developing the risk prediction model (ProlncSig) from lipoxygenase pathway-related lncRNAs for prognosis prediction in breast cancer

Alterations in cellular metabolism are known to play a crucial role in the development and progression of cancer. The lipoxygenase pathway, which controls unsaturated fatty acid metabolism, has been shown to regulate tumour progression and is commonly altered in breast cancer. In this study, we first obtained 11 lipoxygenase pathway genes from the Molecular Signatures Database (MSigDB). We then explored the lipoxygenase pathway-related long non-coding RNAs (lncRNAs) in breast cancer tissues from The Cancer Genome Atlas (TCGA) database. Information from our analysis was used to construct a risk prediction model (ProlncSig) to predict breast cancer prognosis. We found that ProlncSig could accurately identify breast cancer patients that had significantly shorter overall survival from those that had longer overall survival. Moreover, ProlncSig performs better in predicting prognosis than the clinicopathological features. Furthermore, GO and KEGG enrichment analysis showed that ProlncSig risk score had a high correlation with immune signature. We developed and validated an accurate prognostic risk prediction model (ProlncSig) based on lipoxygenase pathway-related lncRNAs, which has strong potential to provide prognostic information and may provide novel guidance for immunotherapeutic strategies for breast cancer patients.