RNA binding protein PCBP2 regulates pancreatic ß cell function and adaptation to glucose

Glucose plays a key role in shaping pancreatic ß cell function. Thus, deciphering the mechanisms by which this nutrient stimulates ß cells holds therapeutic promise for combating ß cell failure in type 2 diabetes (T2D). ß cells respond to hyperglycemia in part by rewiring their mRNA metabolism, yet the factors governing these changes remain poorly understood. Here, we interrogate the transcriptomes of control ß cells and mutant ß cells lacking the RNA binding protein PCBP incubated with low or high glucose for 72 hours. Overall design: RNASeq was performed in control and Pcbp2 null ß cells exposed to low or high glucose for 72 hours.