Skeletal muscle unloading affects muscle progenitor cells functional activity

In this work we employed classic skeletal muscle unloading rat model to determine how hindlimb suspension (HS) affects functional activity of skeletal muscle progenitor cells (SMPC). We have purified SMPC from m. soleus from control rats and after 1, 3, 7 and 14 days of exposure (HS1, HS3, HS7, HS14).本研究采用经典骨骼肌去负荷大鼠模型，旨在探究后肢悬吊（hindlimb suspension, HS）对骨骼肌祖细胞（skeletal muscle progenitor cells, SMPC）功能活性的影响。我们分别从对照组大鼠以及经1、3、7、14天悬吊处理的后肢悬吊模型大鼠（分别记为HS1、HS3、HS7、HS14组）的比目鱼肌（m. soleus）中纯化获得骨骼肌祖细胞。