儿童青少年抑郁症患者血浆非靶向代谢组数据集

儿童和青少年重度抑郁症在全球范围内是一种反复发作和致残的疾病，但其病理生理学仍不清楚，可用的有效治疗方法有限。在这项研究中，我们试图确定儿童和青少年抑郁症特有的代谢变化，最终目的是开发潜在的生物标志物，以帮助诊断和有效治疗这个年龄组的抑郁症。对纳入对象进行静脉采血，基于配备四极杆飞行时间质谱仪的超高效液相色谱对血浆样本进行代谢分析，以探索患有 重度抑郁症的儿童和青少年抑郁症的潜在生物标志物。最后，我们还将儿童和青少年的代谢组学数据与我们以前的成人重度抑郁症的代谢组学数据进行了比较，以记录不同年龄组的共同和独特的代谢变化。

Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling global health condition, yet its pathophysiology remains unclear and effective treatment options are limited. In this study, we sought to identify the metabolic changes specific to MDD in children and adolescents, with the ultimate aim of developing potential biomarkers to aid in the diagnosis and effective treatment of depression in this population. Venous blood samples were collected from enrolled participants, and metabolomic profiling of plasma samples was performed using ultra-high performance liquid chromatography (UHPLC) coupled with a quadrupole time-of-flight mass spectrometer (Q-TOF MS) to explore potential biomarkers for pediatric and adolescent MDD. Finally, we compared the metabolomic data from children and adolescents with our previously generated metabolomic dataset of adult MDD to document the shared and distinct metabolic alterations across different age groups.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于儿童青少年抑郁症患者的血浆非靶向代谢组学研究，旨在通过分析血浆样本中的代谢物变化，识别潜在的生物标志物以辅助诊断和治疗。数据集包含5个文件，总数据量16.7MB，采用超高效液相色谱-质谱技术进行分析，并比较了与成人抑郁症数据的异同，以揭示年龄特异性代谢特征。