Fragility fractures might be predicted by the overall cardiovascular burden in endogenous Cushing syndrome

Endogenous CS represents a complex condition associated with a negative impact on long-term mortality and morbidity. Among the various complications, cardiovascular and skeletal issues stand out as particularly debilitating . However, these intriguing findings indicate the overall burden of cardiovascular morbidity as potential novel shared predictors of damage affecting the bone-vascular axis, and impacting the risk of fracture, extending beyond the mere degree of cortisol excess.
The present study is the first that offers a holistic assessment of the interplay between fracture risk, bone quality, and cardiovascular morbidity in overt endogenous CS.