Sjogren's syndrome OCTA data.xlsx

Sjogren’s syndrome (SS) is a long-term rheumatic autoimmune disease that affects multiple organs. It is not known whether ocular changes are relevant to the diagnosis of SS. This was addressed in the present study by examining microvascular changes in the retina of SS patients by optical coherence tomography angiography (OCTA).Individuals with SS and healthy controls were enrolled (n=12 per group). An en-face OCTA scan was performed on each eye. Images were segmented into 9 subregions and macular retinal thickness (RT) and superficial vessel density (SVD) were measured and compared between the 2 groups.Visual acuity (VA) differed significantly between SS patients (24 eyes) and controls (24 eyes) (P&lt;0.001). In SS patients, inner RT was reduced in the inner superior region, outer RT was reduced in the outer nasal (ON) region, and full RT was reduced in the ON region compared to the control group (P&lt;0.05). RT was negatively correlated with serum IgG level in the outer and full retina at ON regions (P &lt; 0.05). SVD in the inner nasal, ON, and inner temporal regions was significantly lower in SS patients than in control subjects (P&lt;0.05). SVD was positively correlated with full RT in the ON region in SS patients (P&lt;0.05). The areas under the receiver operating characteristic curves for the diagnostic sensitivity of outer RT and full RT in the ON region for SS were 0.828 (95% confidence interval [CI]: 0.709–0.947) and 0.839 (95% CI: 0.715–0.963), respectively.The study was conducted in accordance with the Helsinki Declaration and was approved by the hospital’s ethics council. Before signing the informed consent statement, all participants fully understood the research methods and objectives.<br><br>