Some conserved pathways and interventions of aging.

**There is indirect evidence that each of these is associated with health span or longevity in humans. For specific examples, see references [8–49] and S1 Text. Abbreviations: AMPK, 5ʹ adenosine monophosphate-activated protein kinase; ILS, insulin-like signaling; mTOR, mechanistic target of rapamycin; NAD, nicotinamide adenine dinucleotide; SOD, superoxide dismutase. Some conserved pathways and interventions of aging.