Data_Sheet_1_Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis.docx

ObjectivesStudies have established a link between periodontal disease and cardiovascular disease (CVD), but it is unclear whether there is a sex difference in their association.MethodsThe PubMed, Embase, and Cochrane databases were searched until June, 21 2022. Cardiovascular outcomes included any CVD, myocardial infarction (MI), coronary heart disease (CHD), or stroke. Studies reported the prevalence of CVD in patients with periodontal disease and the relationship between periodontal disease and CVD. The study is registered with PROSPERO (CRD42022333663). The level of evidence and recommendations is assessed by the Grading of Recommendations for Assessment, Development and Evaluation (GRADE).ResultsTwenty-six studies were included. In patients with periodontal disease, the prevalence of CVD was 7.2% [9 studies; 95% confidence interval (CI): 2.7–13.6%], and prevalence for CHD, hypertension, stroke, and heart failure was 6.6, 25.3, 1, and 1.1%, respectively. There was a significant association between periodontal disease and CVD in men [odds ratio (OR) = 1.22; 95% CI: 1.12–1.34] and women (OR = 1.11; 95% CI: 1.05–1.17), with no significant sex difference (P > 0.05).ConclusionCardiovascular disease is relatively common in patients with periodontal disease, and an increased risk of CVD is associated with periodontal disease independent of sex. Interventions targeting periodontal disease may be beneficial for CVD.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022333663.

研究已确立牙周病与心血管疾病（CVD）之间的关联，然而，尚不明确两者之间是否存在性别差异。研究方法：检索了PubMed、Embase和Cochrane数据库，截止至2022年6月21日。心血管疾病结果包括任何CVD、心肌梗死（MI）、冠心病（CHD）或中风。研究报道了牙周病患者中CVD的患病率以及牙周病与CVD之间的关系。本研究已在PROSPERO（CRD42022333663）注册。通过 GRADE（评估、发展和评价推荐意见分级）对证据水平和推荐意见进行评估。研究结果：纳入了26项研究。在牙周病患者中，CVD的患病率为7.2%（9项研究；95%置信区间（CI）：2.7–13.6%），CHD、高血压、中风和心力衰竭的患病率分别为6.6%、25.3%、1%和1.1%。在男性和女性中，牙周病与CVD之间存在显著关联[男性：比值比（OR）= 1.22；95% CI：1.12–1.34；女性：OR = 1.11；95% CI：1.05–1.17]，且无显著性别差异（P > 0.05）。结论：在牙周病患者中，心血管疾病相对较为常见，且与牙周病相关的CVD风险增加与性别无关。针对牙周病的干预措施可能对心血管疾病有益。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/，标识符CRD42022333663。