Structural characterization of Thomasclavelia ramosa IgA peptidase (IgAse)
收藏DataCite Commons2026-02-21 更新2026-05-03 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-DC-2354657697
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资源简介：
Immunoglobulin A (IgA) protects mucosal surfaces against microbial infections. In response, many bacteria have evolved proteases that specifically target this antibody. Among them is the M64 IgA peptidase (IgAse), a ~140 kDa membrane-bound metallopeptidase produced by the gut commensal Thomasclavelia ramosa, which cleaves both IgA1 and IgA2 subclasses. Using small-angle X-ray scattering (SAXS), we characterized its flexibility and domain organization, and through cryo-electron microscopy (cryo-EM), we determined its structure at 2.8 Å resolution.
提供机构：
European Synchrotron Radiation Facility
创建时间：
2026-02-21
