Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE)

Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE) Descriptor: 4-[(1S,5R,6R)-6-amino-1-methyl-3-azabicyclo[3.2.0]hept-3-yl]-6-fluoro-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, DNA gyrase subunit B, TERTIARY-BUTYL ALCOHOL Authors: Bensen, D.C, Akers-Rodriguez, S, Tari, L.W. Deposit date: 2013-05-17 Release date: 2014-01-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity To be Published

粪肠球菌（Enterococcus faecalis）DNA旋转酶（DNA gyrase）ATP结合结构域与小分子抑制剂4-[(1S,5R,6R)-6-氨基-1-甲基-3-氮杂双环[3.2.0]庚-3-基]-6-氟-N-甲基-2-[(2-甲基嘧啶-5-基)氧基]-9H-嘧啶并[4,5-b]吲哚-8-胺形成的复合物；描述项：4-[(1S,5R,6R)-6-氨基-1-甲基-3-氮杂双环[3.2.0]庚-3-基]-6-氟-N-甲基-2-[(2-甲基嘧啶-5-基)氧基]-9H-嘧啶并[4,5-b]吲哚-8-胺、DNA旋转酶B亚基、叔丁醇（TERTIARY-BUTYL ALCOHOL）；作者：本森（Bensen, D.C.）、阿克斯-罗德里格斯（Akers-Rodriguez, S）、塔里（Tari, L.W.）；存放日期：2013年5月17日；发布日期：2014年1月15日；最后修改日期：2024年2月28日；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.75埃（Å）；引用文献：一类具备广谱抗菌活性的IIA型拓扑异构酶抑制剂新类别（待发表）