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Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3‑Mediated Reductive Cyclopropanation

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Figshare2016-02-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Diastereoselective_Synthesis_of_Functionalized_Spirocyclopropyl_Oxindoles_via_P_NMe_sub_2_sub_sub_3_sub_Mediated_Reductive_Cyclopropanation/2237833
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A P­(NMe2)3-mediated reductive cyclopropanation reaction of α-keto esters or amides with isatin-derived alkenes has been developed, providing efficient and diastereoselective synthesis of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon quaternary centers. This reaction also represents a complementary and nonmetal-involving protocol for the challenging cyclopropanation of electron-deficient alkenes.
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2016-02-16
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