Impact of carbapenem-resistant Klebsiella pneumoniae Infection on Gut Microbiota and Host Immunity: A Case-Control Study

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant global health threat. The gut microbiota is a crucial regulator of host immunity and a known reservoir for opportunistic pathogens like K. pneumoniae. However, the reciprocal impact of a systemic CRKP infection on the gut microbial ecosystem and the host's systemic immune response remains inadequately characterized.