The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon

The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... Authors: Kong, L, Connelly, S.C, Wilson, I.A. Deposit date: 2014-05-25 Release date: 2015-04-08 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chem.Biol., 11, 2016

带有增强型芳香序列子（Enhanced Aromatic Sequon）修饰的人IgG Fc结构域的晶体结构：其修饰组分包括2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)]-β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)-β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，以及甘油（GLYCEROL）等。作者：Kong L、Connelly S.C、Wilson I.A。沉积日期：2014年5月25日；发布日期：2015年4月8日；最后修改日期：2024年10月9日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.99埃（Å）。引用文献：《通过工程化引入增强型芳香序列子稳定抗体CH2结构域》，刊载于《ACS化学·生物学》（Acs Chem.Biol.），2016年，第11卷。