Transcriptomic analysis after proton and neutron therapy

Study of molecular signatures in three types of objects after proton (human) and neutron (cell model, xenograft) irradiation The aim of the study was to establish common and distinct molecular signatures activated by particle therapy in three types of objects - patient material (tumor tissue and peritumoral tissue) from patients with head and neck cancer, in a cell line of a human larynx strain in the form of a tumoroid obtained at ultra-low adhesion plastic and in a cell strain of the larynx, implanted subcutaneously in an immunodeficient mouse. Irradiation was carried out at an installation at the Medical Radiological Research Center named after. A.F. Tsyba with a final total dose of 10 Gy.