Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216

Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216 Descriptor: (2S)-2-(3,4-dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide, Pregnenolone sulfate, Transient receptor potential cation channel, ... Authors: Yin, Y, Park, C.G, Feng, S, Zhang, F, Guan, Z, Sharma, K, Borgnia, M.J, Im, W, Lee, S.-Y. Deposit date: 2024-03-14 Release date: 2025-01-22 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.82 Å) Cite: Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3. Nat.Struct.Mol.Biol., 32, 2025与神经甾体（neurosteroid）硫酸孕烯醇酮及合成激动剂CIM 0216结合的小鼠TRPM3 α2通道的冷冻电镜（Cryo-EM）结构 描述项：(2S)-2-(3,4-二氢喹啉-1(2H)-基)-N-(5-甲基-1,2-恶唑-3-基)-2-苯乙酰胺、硫酸孕烯醇酮、瞬时受体电位阳离子通道（Transient receptor potential cation channel）…… 作者：Yin Y、Park C.G、Feng S、Zhang F、Guan Z、Sharma K、Borgnia M.J、Im W、Lee S.-Y. 存入日期：2024-03-14 发布日期：2025-01-22 最后修改日期：2025-05-28 方法：冷冻电子显微镜（分辨率3.82 Å） 引用文献：TRPM3的神经甾体与抗惊厥剂调控的分子机制. 《自然-结构与分子生物学》（Nat.Struct.Mol.Biol.）, 32卷, 2025