Changes in gene expression in a pancreatic cancer cell line and a chemoresistant line on treating with the drug CM03 Overall design: Changes at 6 h and 24 h were evaluated with RNA-seq with respect to

NIAID Data Ecosystem40

Transcriptomic profile of replicating NAFLD hepatocytes (from High-Fat High-Sucrose Diet - HFHS and Choline-Deficient High-Fat Diet - CDHFD).. Transcriptomic profile of replicating NAFLD hepatocytes (from High-Fat High-Sucrose Diet - HFHS and Choline-Deficient High-Fat Diet - CDHFD).

NAFLD肝细胞转录组

复制应激

C57Bl6/J male mice were put on different diets at 5 weeks of age, with a standard diet (SD) or a High-Fat High-Sucrose Diet (HFHS) or a Choline-Deficient High-Fat Diet (CDHFD) during 6 months. Primary

NIAID Data Ecosystem30

Transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor–resistant pancreatic ductal adenocarcinoma

胰腺癌耐药机制

LDHA抑制剂耐药

Metabolic reprogramming, due in part to the overexpression of metabolic enzymes, is a key hallmark of cancer cells. Lactate dehydrogenase (LDHA), a metabolic enzyme that catalyzes the interconversion

NIAID Data Ecosystem70

Transcriptomic analysis of Panc10.05 cells treated with indisulam

胰腺癌耐药机制

药物转录组学

Indisulam is an abandoned drug that acts as a molecular glue, inducing degradation of splicing factor RBM39 through interaction with CRL4DCAF15. We generated spontaneoulsy indisulam-resistant Panc10.0

NIAID Data Ecosystem30

Supplementary Table from Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs

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