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Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine Neurofibromatosis-1 optic glioma

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NIAID Data Ecosystem2026-03-12 收录
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Contributing factors to pediatric glioma formation Overall design: TVZ neuroglial progenitor cells (NPCs) were analyzed over the course of mouse brain development. FACS-isolated progenitors were assessed for functional and molecular differences. The impact of different germline Nf1 mutations on TVZ NPC properties was analyzed using genetically engineered mice.

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2021-04-23
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