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Regulation of blood-brain barrier by astrocyte through mitochondrial transfer

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The subset of astrocytes that express Dmp1 were considered to wrap around blood vessels. We used scRNA-seq to investigate the mobility of mitochondria from astrocytesDMP1. Brain single cells with mito-COX8Dendra2 fluorescence from Dmp1Cre-COX8Dendra2 mice were enriched by Fluorescence-activated cell sorting (FACS) according to the presence of Dendra2 signal and analyzed using scRNAseq.

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