Identification of enhancer elements that direct long-range responses to tissue injury

The goal of this study is to unveal the responses of uninjured tissue to distant tissue injury and the structures required for long-range responses to tissue injuries. we profiled responses by the brain and kidney in zebrafish to massive injuries of the heart and identified cebpd transcript induction in both tissue. We also identified and demonstrated that a 1.2kb cebpd downstream element is capable and neccessary for the induction of cebpd in the brain after cardiac injury. Brain and kidney RNA-seq and ATAC-seq profiling after cardiac injury; cebpd+/+ and cebpd-/-brain RNA-seq profiling after cardiac injury