Pathological lesions and antigen distribution in tissues of nonhuman primates infected with H5N1 viruses.

Animals were vaccinated twice (4-week interval) with AH/AAca and challenged with AH/05 or BHG/05 virus. Tissues for pathological examination were collected 3 days after viral challenge. Tra, trachea; Bro, Bronchus; TBLN, tracheobronchial lymph node.
bPathological lesions/viral antigens. −, no pathological change/antigen. +, limited pathological change/antigen. ++, moderate pathological change/antigen. +++, severe pathological change/abundant antigen.